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Estimate based on data from Surveillance, Epidemiology, and End Results (SEER) registries.
From a meta-analysis of 78 randomized trials in the Early Breast Cancer Trialists’ Collaborative Group (EBCTCG) database of 74,194 women with ER+ breast cancer who had 5 years of scheduled endocrine therapy. Patients with T0 and T3, and those with N3 disease, were not included in the analysis.1
Proportion of stage II HR+/HER2– disease estimated to be addressed by recent treatment advancements.
Percentages calculated based on approval of abemaciclib for stage II or III node-positive disease, and, for olaparib, prevalence of BRCA1 and BRCA2 germline mutations in ER+ breast cancer.
Stage II (N0, N1) disease accounts for a sizable proportion of HR+/HER2– eBC diagnoses and approximately 1 in 3 patients are at risk of distant recurrence
Recently approved treatments are limited in use to <15% of eBC cases, leaving most patients with stage II (N0, N1) disease without an optimized therapy
Up to nearly 1 in 5 patients discontinue these new therapies due to tolerability challenges—leaving them at increased risk of recurrence
ARs, adverse reactions; ER+, estrogen receptor-positive; gBRCAm, germline BRCA–mutated; HER2–, human epidermal growth factor receptor 2-negative; HR+, hormone receptor-positive.
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Factors associated with intentional and unintentional non-adherence to adjuvant endocrine therapy following breast cancer. Eur J Cancer Care (Engl). 2018;27(1). doi:10.1111/ecc.12601 17. Fontein DBY, Nortier JWR, Liefers GJ, et al. High non-compliance in the use of letrozole after 2.5 years of extended adjuvant endocrine therapy. Results from the IDEAL randomized trial. Eur J Surg Oncol. 2012;38(2):110-117. doi:10.1016/j.ejso.2011.11.010 18. Hershman DL, Kushi LH, Shao T, et al. Early discontinuation and nonadherence to adjuvant hormonal therapy in a cohort of 8,769 early-stage breast cancer patients. J Clin Oncol. 2010;28(27):4120-4128. doi:10.1200/JCO.2009.25.9655 19. Tutt ANJ, Garber JE, Kaufman B, et al; OlympiA Clinical Trial Steering Committee and Investigators. Adjuvant olaparib for patients with BRCA1- or BRCA2-mutated breast cancer. N Engl J Med. 2021;384(25):2394-2405. doi:10.1056/NEJMoa2105215 20. Rugo HS, O’Shaughnessy J, Boyle F, et al; monarchE Committee Members. 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A phase III, multicenter, randomized, open-label trial to evaluate efficacy and safety of ribociclib with endocrine therapy as an adjuvant treatment in patients with hormone receptor-positive, HER2-negative, early breast cancer (New Adjuvant TriAl with Ribociclib [LEE011]: NATALEE). EduraCT identifier: 2018-002998-21. Posted January 18, 2019. Accessed November 1, 2022. https://www.clinicaltrialsregister.eu/ctr-search/trial/2018-002998-21/ES 24. A trial to evaluate efficacy and safety of ribociclib with endocrine therapy as adjuvant treatment in patients with HR+/HER2- early breast cancer (NATALEE). ClinicalTrials.gov identifier: NCT03701334. Updated February 18, 2022. Accessed October 31, 2022. https://clinicaltrials.gov/ct2/show/NCT03701334?term=NCT03701334&draw=2&rank=1